WebMoreover, we identify a substrate of PKCε, Ephexin5, whose early-elevated expression in developing neurons may in part explain the mechanism by which PKCε plays seemingly opposing roles that depend on neuronal maturity. Schaffer et al. define roles in developing hippocampal neurons for specific PKCs, linking neuronal PKCε activation to ...
A dual role for the RhoGEF Ephexin5 in regulation of dendritic …
WebFeb 27, 2024 · EXPH5 exophilin 5. EXPH5. exophilin 5. Gene ID: 23086, updated on 27-Feb-2024. Gene type: protein coding. Also known as: EBS4; SLAC2B; SLAC2-B. See all … WebApr 1, 2024 · Notably, Ephexin5 is ubiquitinated and degraded by the ubiquitin proteasome system (UPS) in response to stimulation of the EphB2 receptor tyrosine kinase (Margolis et al., 2010). Furthermore, Ephexin5 acts as a negative regulator of spine and synapse density in neuronal cultures (Margolis et al., 2010); however, whether Ephexin5 acts to inhibit ... picking someone up from floor
PKCε Inhibits Neuronal Dendritic Spine Development through Dual ...
WebOct 29, 2010 · Ephexin5 Is a GEF that Activates RhoA (A) Lysates from 293 cells transfected with empty vector (Ctrl) or E5-Myc overexpressing vector (WT) were assayed … WebApr 1, 2024 · Ephexin5 is not the sole target of the proteasome in regulating spine outgrowth. We previously proposed a model of activity-dependent spine outgrowth in which neural activity led to local proteasome activation that then caused the degradation of inhibitory factors blocking spine outgrowth (Hamilton et al., 2012). If E5 were the sole … WebOct 29, 2010 · Ephexin5 suppresses this activity, and EphB2 relieves this repression by phosphorylating and directing Ephexin5 for degradation by the E3 ligase Ube3A . These findings cement EphBs as a key regulator of excitatory synapse development and suggest the interesting possibility that other known synaptogenic factors will have similarly … top 10 编程语言 tiobe 指数走势