Gamendazole
WebDetect EF1α using this Anti-EF1α Antibody, clone CBP-KK1 validated for use in IP & WB. - Find MSDS or SDS, a COA, data sheets and more information. Gamendazole is a drug candidate for male contraception. It is an indazole carboxylic acid derived from lonidamine (LND). It has been shown to reduce fertility in male rats without affecting testosterone levels, but human clinical trials have not been started.
Gamendazole
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WebH2-Gamendazole . CAS: 877768-84-8 . Chemical Name: H2-GMZ; 3-(1-(2,4-Dichlorobenzyl)-6-(trifluoromethyl)-1H-indazol-3-yl)propanoic acid For Lab R&D Uses Only. Cat No: GLXC-10118 . Purity: >98% (HPLC) Storage: Refrigerator (4 °C) Product Description: Novel non-hormonal male contraceptive agent, causing reversible infertility … WebJul 2, 2024 · gamendazole (H2-GMZ), is an indazole carboxylic acid analog that accumulates over 10 times more in the testes compared to other organs. However, the mechanism(s) by which H2-GMZ circumvents the BTB are unknown. This study describes the physiological characteristics of the carrier-mediated process(es) that permit H2-GMZ
WebApr 12, 2024 · Here, we have identified the interaction site of the contraceptive drug gamendazole using computational modeling. The drug was previously described as a ligand for eukaryotic translation elongation factor 1-α 1 (eEF1A1) and found to be a potential target site for derivatives of 2-phenyl-3-hydroxy-4(1 H)-quinolinones (3-HQs), which exhibit … WebJul 1, 2011 · To meet this need, we have developed H2-Gamendazole (H2-GMZ), an orally active anti-spermatogenic indazole carboxylic acid with potent antifertility effects, and no adverse side effects at doses needed to induce reversible infertility. We report efficacy results using oral doses of H2-GMZ in mice, rats, rabbits, and non-human primates …
WebJul 25, 2024 · In addition, the utility of the synthetic methodology was demonstrated via the synthesis of 6-SF 5-gamendazole – a fully matched analog of the experimental male contraceptive gamendazole, which has a 6-CF 3-substituted indazole core. This article is part of the themed collection: ... WebNov 22, 2024 · The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease. Am J Physiol Renal Physiol 323: F492–F506, 2024. doi: 10.1152/ajprenal.00095.2024. Link Google Scholar; 5. Davidow CJ, Maser RL, Rome LA, Calvet JP, Grantham JJ.
WebJul 2, 2024 · gamendazole (H2-GMZ), is an indazole carboxylic acid analog that accumulates over 10 times more in the testes compared to other organs. However, the …
WebDec 6, 2024 · (B) Formal synthesis of gamendazole, a drug candidate for male contraception, was accomplished in 61% overall yield within three steps through a 1H … seven points post officeWebH2-Gamendazole C18H13Cl2F3N2O2 CID 44176633 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ... seven points wellness solutionsWebSep 9, 2024 · We have examined the effectiveness of the indazole carboxylic acid, H2-gamendazole (H2-GMZ), a derivative of lonidamine, to inhibit these processes and cyst … seven point water haulingWebNov 22, 2024 · H2-gamendazole (H2-GMZ) inhibition of autosomal dominant polycystic kidney disease (ADPKD) kidney cell signaling. Mutation of polycystin 1 ( PKD1 ) and … seven ponds and a few raindropsWebSep 27, 2024 · H2-gamendazole (H2-GMZ) blocks heat shock protein (Hsp)90 function in primary human autosomal dominant polycystic kidney disease (ADPKD) cells. A: ADPKD cells were stained with anti-Hsp90 antibody (green) to show the presence of Hsp90 in the cytoplasm and nucleus. Cells were counterstained with the nuclear stain DAPI (blue). the townhomes at woodmill creek reviewsWebSep 14, 2024 · H2-gamendazole steps in at this crucial stage, snipping away this tether before sperm can really become fully developed, which means the suckers are destined … the townhomes at wisteria hillsWebGamendazole. Interestingly, gamendazole also induces a significant increase in testicular interleukin levels (Tash et al. 2008b) and it was recently shown that interleukin 1α induced BTB disruption possibly via its effects on the actin cytoskeleton (Sarkar et al. 2008). seven points texas movie theatre