WebDec 31, 2013 · The transcriptional code that programs cardiac hypertrophy involves the zinc finger-containing DNA binding factors GATA-4 and GATA-6, both of which are required to mount a hypertrophic response of the adult heart. Here we performed conditional gene deletion of Gata4 or Gata6 in the mouse heart in conjunction with reciprocal gene … WebAug 1, 2004 · GATA-4 and -6 regulate expression of several cardiac-specific genes, and during murine embryonic development, GATA-4 is essential for proper cardiac …
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WebSep 11, 2024 · The bone morphogenetic protein (Bmp) signaling pathway and the basic helix–loop–helix (bHLH) transcription factor Hand1 are known key regulators of cardiac development. In this study, we investigated the Bmp signaling regulation of Hand1 during cardiac outflow tract (OFT) development. In Bmp2 and Bmp4loss-of-function embryos … WebSep 15, 2006 · First, Gata4 functions as an upstream regulator of an Erbb3 - Erk pathway necessary for EMT, and second, Gata4 acts to promote cushion mesenchyme growth and remodeling. Keywords: Heart … old town tavern morristown
GATA4 mutations cause human congenital heart …
WebSep 26, 2006 · We found that partial Gata4 deficiency resulted in mild systolic and diastolic dysfunction at baseline and overt heart failure after pressure overload. Our results … WebMar 3, 2010 · Major contribution of gata4 + cardiomyocytes to heart regeneration. a, gata4:ERCreER; β-act2:RSG animals injected once daily with vehicle (left) or 4-HT at 5–7 dpa, before collection at 9 (center; n = 5) or 14 dpa (right; n = 6). EGFP fluorescence (arrows) is observed at injury borders by 9 dpa and within the injury site by 14 dpa. WebGATA4 is an essential transcriptional regulator required for gonadal development, differentiation, and function. In the developing testis, proposed GATA4-regulated genes include steroidogenic factor 1 (Nr5a1), SRY-related HMG box 9 (Sox9), and anti-Müllerian hormone (Amh). ... Did you know that heart disease and stroke is the #1 cause of ... is a dodge charger a sport car