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Topbp1

Web8. jún 2024 · Replication stress stimulates TOPBP1–Treacle interaction. (A) Intact and APH-treated (1 µM, 12 h) HeLa cells were stained for TOPBP1 (green) and Treacle (magenta) and analyzed by SIM. Enlarged nucleoli are shown in the insets. Colocalization analysis was performed on the merged images. Graphs illustrate quantification in arbitrary units of ... Web1. feb 2016 · Topoisomerase IIβ-binding protein 1 (TOPBP1) participates in DNA replication and DNA damage response; however, its role in DNA repair and relevance for human …

CK2 kinase-mediated PHF8 phosphorylation controls …

Web12. mar 2015 · TOPBP1 is a novel TOP2A-interacting protein. To understand the mechanism of TOP2A recruitment to UFBs, we undertook an unbiased proteomic approach to map TOP2A’s protein–protein interactions. Web2. aug 2024 · The role of TOPBP1 goes beyond the typical replication stress response; it interacts with the low-complexity nucleolar protein Treacle (also referred to as TCOF1) and forms large Treacle-TOPBP1 foci inside the nucleolus. In response to replication stress, Treacle and TOPBP1 facilitate ATR signaling at stalled replication forks, reinforce ATR ... philips 272m8cz review https://kibarlisaglik.com

TopBP1 Controls BLM Protein Level to Maintain Genome Stability

Web27. apr 2024 · TOPBP1 (Topoisomerase IIβ-binding protein 1) mediates protein–protein interaction and DNA damage response (DDR) activation in DNA damage sensing and … Web18. máj 2010 · Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and … Web11. nov 2024 · h, Quantification of CIP2A and HA-TOPBP1 mitotic IRIF in DLD1 cells expressing variants of sgRNA-resistant TOPBP1 (TOPBP1*) or EV encoding only the HA … philips 272e2f/11

The CIP2A-TOPBP1 complex safeguards chromosomal stability

Category:TOPBP1 protein expression summary - The Human Protein Atlas

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Topbp1

The CIP2A–TOPBP1 axis safeguards chromosome stability and is …

WebCells were harvested and immunoblotted with the indicated antibodies. (B) TopBP1 was degraded via a proteasome-mediated pathway in PHF8 KO cells. MCF10A-derived PHF8 KO cells were treated with 20 ... Web18. mar 2024 · TopBP1 phase separation in vitro occurred also in the complex environment of a nuclear extract, where multiple homotypic and heterotypic interactions could …

Topbp1

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Web18. mar 2024 · TopBP1 phase separation in vitro occurred also in the complex environment of a nuclear extract, where multiple homotypic and heterotypic interactions could influence the capacity of TopBP1 to self-assemble. Third, TopBP1 condensation was highly sensitive to key amino acid substitutions and post-translational modifications in the AAD. Web18. okt 2024 · CG和non-CG甲基化是否可以协同调控植物发育，它们同时丢失会对植物正常发育产生什么影响还有待探究。. 2024年10月16日，New Phytologist杂志在线发表了蛋白质与植物基因研究国家重点实验室、北京大学现代农学院钱伟强研究团队题为“Deciphering the synergistic and ...

Web12. mar 2015 · Here, we identify TOPBP1 as a novel interactor of TOP2A, and reveal that it is required for TOP2A recruitment to ultra-fine anaphase bridges (UFBs) in mitosis. Webpred 15 minútami · Using this approach, we identified a set of genomic loci within the proximal promoter region of significantly down-regulated genes TOPBP1, ZHX2, BCL2L1 and CCR1, which were subsequently analysed using ChIP-qRT-PCR (Additional file 1: Fig. S1). i-BET858 treatment caused minor changes in BRD2, BRD3 and BRD4 enrichment in the …

Web24. feb 2024 · TopBP1 Antibody (B-7) is an IgG 1 κ mouse monoclonal TopBP1 antibody (also designated TopBP1 antibody) suitable for the detection of the TopBP1 protein of human origin by WB, IP, IF and ELISA. TopBP1 Antibody (B-7) is available as both the non-conjugated anti-TopBP1 antibody form, as well as multiple conjugated forms of anti … WebTOPBP1 INFORMATION. Proteini. Full gene name according to HGNC. DNA topoisomerase II binding protein 1. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. TOPBP1 (Dpb11, KIAA0259, TOP2BP1) Protein classi. Assigned HPA protein class (es) for the encoded protein (s).

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Web25. jan 2016 · TOPBP1 is a large, nine BRCT domain–containing protein with essential roles in cellular processes, including DNA repair, replication, and transcription (Sokka et al., … trust ford sherburnWeb19. mar 2015 · Human TopBP1 plays essential roles in DNA replication and replication checkpoint control. In our recent paper “TopBP1 controls BLM protein level to maintain genome stability,” we provided evidence suggesting that TopBP1 has an unexpected role in suppressing sister chromatid exchange (SCE) and that this function is independent of its … trust ford west byfleetWeb8. jan 2024 · High TopBP1 mRNA and protein expression is associated with endometrial cancer. Studies identify the SIRT1-TopBP1 axis as a key signaling mode in the regulation … philips 272s1Web附件： 2011年度浙江省自然科学基金拟资助 省杰出青年科学基金项目清单 项目编号 项目名称 申请者 依托单位 r1110003 philips 272s1aeWeb21. mar 2024 · TOPBP1 (DNA Topoisomerase II Binding Protein 1) is a Protein Coding gene. Diseases associated with TOPBP1 include Ataxia-Telangiectasia and Seckel Syndrome . … philips 272s1ae/00Web1. máj 2024 · TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome … trustford weston super mareWeb4. feb 2024 · The TOPBP1 protein was expressed in Sf9 insect cells using the Bac-to-Bac expression system according to the manufacturer’s recommendation. Purification was carried out by affinity chromatography using the same buffers and procedure as used for BLM. Human RPA was expressed in E. coli . Briefly, the protein was purified using ÄKTA … trust for kids while alive